NCT00899145: Breast-cancer risk modifiers in BRCA1/BRCA2 carriers

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Withdrawn

Study: Genetic modifiers of breast-cancer risk in BRCA1/BRCA2 mutation carriers, linked to Gynecologic Oncology Group resources and the CIMBA consortium. 1 2

Design and measurements: This observational project proposed using existing DNA and clinical data from GOG-0199 participants, testing selected genetic variants, and combining coded clinical and epidemiological information with other centers' data. The aim was to investigate whether additional variants modify cancer risk among carriers. 1 2

What is established: The inspected record is withdrawn, with a July 2017 update. No variant-specific risk estimate or validated clinical prediction test was verified for this identifier. It is not a treatment trial, and a planned association analysis cannot establish that a genetic test improves patient outcomes. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00899145. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00899145. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.