NCT00882492: Intravenous GLP-1 during cardiac surgery

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Completed

This trial tested intravenous native GLP-1 during cardiac surgery, not a modern long-acting weight-loss injection. Patients undergoing elective surgery with cardiopulmonary bypass received GLP-1 or placebo, with protocol-directed insulin available in both groups. 1 2 3 4

The original publication analyzed 77 patients: 37 GLP-1 and 40 placebo, compared with 80 enrolled in the registry. Mean glucose over the intraoperative period was 12.2 mg/dL lower with GLP-1 (95% CI 2.3–22; P=.015). The report also states that hypoglycemia incidence did not differ significantly. 1 2 3

This supports an intraoperative glucose-lowering effect under a controlled anesthesia protocol. It does not establish reduced mortality, better long-term diabetes control, or the safety of continuing or withholding other GLP-1 medicines around surgery; those are different questions. 1 2 3

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00882492. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00882492. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.

3. PubMed — Kohl et al.: original randomized studyResearch publication · Publication abstract read via Europe PMC; identifier and title cross-checked. Checked 2026-10-10. Full paper was not independently re-read for this update; abstract details should not be extended beyond what it reports.

4. Original journal abstract — Original journal abstractCited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.