NCT00841841: Dipyrone versus paracetamol after tooth extraction

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Completed

Study: Dipyrone, also called metamizole, versus acetaminophen/paracetamol for pain after third-molar extraction in Brazil. 1 2

Design and measurements: The completed record lists 30 actual participants, 15 per treatment, aged 18–35. The research regimens were dipyrone 500 mg every six hours or paracetamol 750 mg every six hours, assessed over 48 hours. Participants also received dexamethasone 4 mg before surgery, an important cointervention. 1 2

Record inconsistency: The structured field labels allocation nonrandomized, but the narrative says participants were randomly assigned. The study was open-label, with repeated ordinal pain measurements. Without resolving the allocation discrepancy or verifying outcome data, it is not defensible to claim that either drug was superior. These are historical protocol doses, not individualized prescribing advice. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00841841. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00841841. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.