NCT00780299: HYPERDIA: high-cutoff dialysis after cardiac arrest

NCT00780299 is HYPERDIA, a randomized trial of high-cutoff continuous venovenous hemodialysis for post-cardiac-arrest shock. The rationale was removal of circulating inflammatory mediators in patients with severe post-resuscitation circulatory failure. This is different from routine dialysis for chronic kidney failure. 1 2

The original 2019 Resuscitation report is a direct results resource. Its conclusion is negative: the high-cutoff dialysis strategy did not shorten post-resuscitation shock or improve the measured hemodynamic course. The article evaluates vasopressor dependence and other clinical outcomes rather than merely whether a membrane can remove molecules. 3

Accordingly, the biological rationale did not translate into a demonstrated circulatory benefit in this trial. The study was small, so a nonsignificant result should not be interpreted as precise proof that every possible effect is zero. Conversely, laboratory plausibility is not evidence of improved survival or faster recovery. 3

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00780299. Original registration; establishes the exact study identity and registered methods.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00780299. Original registration; establishes the exact study identity and registered methods.

2. ICH GCP — ICH GCP — NCT00780299. Readable reproduction of the sponsor-submitted registration, including the design and dated status fields; not an independent outcome study.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.