NCT00773942: Medication management in older adults: randomized results

NCT00773942 has a published randomized outcomes study—not merely an implementation paper. Touchette and colleagues enrolled 637 adults aged at least 65, with multiple chronic illnesses, at least six prescription medicines and risk of medication-related problems. Participants received usual care, basic medication therapy management, or enhanced management with additional clinical-record information. 1 2

Pharmacists reviewed medicines at baseline and three months, with outcomes assessed through six months. The original abstract reports no difference in potential adverse drug events or healthcare visits between medication-management and usual-care groups. Drug-related problems declined within both intervention groups. 2

Enhanced management also produced fewer medication-list discrepancies than basic management; this process improvement must be distinguished from the absence of demonstrated reduction in potential adverse events or healthcare use. The findings apply to this specific intervention, not all pharmacist services. 2

The separately cited Dolor paper discusses implementation barriers. It is useful for understanding delivery but is not a substitute for the Touchette randomized results. 3

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00773942. Original registration; establishes the exact study identity and registered methods.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00773942. Original registration; establishes the exact study identity and registered methods.

2. PubMed — Touchette et al. (2012). Safety-focused medication therapy management: a randomized controlled trial. Journal of the American Pharmacists Association 52(5):603–612; DOI…Research publication · Publication abstract read via Europe PMC; identifier and title cross-checked. Checked 2026-10-10. Full paper was not independently re-read for this update; abstract details should not be extended beyond what it reports.

3. Dolor et al. (2012). Patient safety-focused medication therapy management: challenges affecting future implementation. American Journal of Managed Care 18(7):e238–e244; PMID 22823552. Companion implementation study, not the main efficacy report — Dolor et al. (2012). Patient safety-focused medication therapy management: challenges affecting future implementation. American Journal of Managed Care 18(7):e238–e244; PMID…Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.