NCT00670293: Dopamine function in anorexia before and after weight restoration

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Completed

This was a mechanistic study of dopamine function in anorexia nervosa before and after weight restoration. The New York State Psychiatric Institute record describes an observational case-control study with 50 actual participants and a completed status in its April 2016 update. 1 2

Participants with anorexia nervosa and healthy comparison participants underwent brain imaging. The protocol used [11C]raclopride PET, MRI, and a methylphenidate challenge to investigate dopamine signaling. Repeat assessment in the anorexia group was planned two to four weeks after weight restoration. 1 2

Methylphenidate was a research probe here, not an established treatment for anorexia. The verified record establishes the design and enrollment; numerical imaging results were not verified. It therefore cannot support a claim that a dopamine abnormality was demonstrated, normalized, or made into a diagnostic test. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00670293. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00670293. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.