NCT00658450: Cognitive rehabilitation after severe malaria in children

NCT00658450 concerns computerized cognitive rehabilitation after severe malaria in Ugandan children, with corresponding registration ISRCTN53183087. It asks whether training can improve cognitive and functional sequelae, not whether it treats the malaria infection itself. 1 2

Bangirana and colleagues' original randomized report included 61 children aged 5–12: 28 assigned to training and 33 to control. Training comprised 16 sessions over eight weeks, starting approximately three months after severe malaria; outcomes were reassessed about one month after training. 3

The primary attention outcome did not improve relative to control. Learning favored training (P=.04), but working memory favored control (P=.04); other cognitive, academic and behavioral outcomes did not show a general benefit. A single favorable secondary measure should therefore not be described as global cognitive recovery. 3

The larger enrollment field in the registry is not the same denominator as the 61-child publication. Nor should findings from later, separately registered Ugandan rehabilitation trials be assigned to this report. 2 3

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00658450. Original registration; establishes the exact study identity and registered methods.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00658450. Original registration; establishes the exact study identity and registered methods.

2. ISRCTN — ISRCTN — ISRCTN53183087. Corresponding primary registration identifying the Ugandan post-malaria cognitive-rehabilitation project.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.

3. Bangirana et al. (2011). Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial. BMC Neurology 11:96; DOI 10.1186/1471-2377-11-96 — Bangirana et al. (2011). Cognition, behaviour and academic skills after cognitive rehabilitation in Ugandan children surviving severe malaria: a randomised trial. BMC Neurology…Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.