NCT00500591: Endometrial biomarkers in premenopausal women with obesity

Study: Endometrial biomarkers in premenopausal women with obesity, reported by Dottino and colleagues in the American Journal of Obstetrics and Gynecology in 2021. 1 2 3

Published data: The cross-sectional cohort prospectively enrolled 97 women with BMI ≥30 and 33 with BMI ≤25, with timed endometrial biopsies and metabolic testing. In histologically normal endometrium, the obesity group had lower expression of progesterone receptor (P=.0027), retinaldehyde dehydrogenase 2 (P=.008), IGF-1 (P=.016), and survivin (P=.042). Several associations persisted after adjustment. Endometrial proliferation did not differ; a separately examined Lynch-syndrome cohort showed a different IGF-1 pattern. 2 3

Interpretation: These tissue findings challenge a simple assumption that obesity uniformly produces a locally estrogen-stimulated endometrium in premenopausal women. They do not show that obesity prevents cancer, validate a screening test, or demonstrate reduced cancer incidence. This was biomarker research, not a prevention-treatment trial. 2 3

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00500591. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00500591. Original study registration: sponsor, design, population, endpoints and dated history.

2. PubMed — Original publication indexed by PubMedResearch publication · Publication abstract read via Europe PMC; identifier and title cross-checked. Checked 2026-10-10. Full paper was not independently re-read for this update; abstract details should not be extended beyond what it reports.

3. Authors’ institutional publication record and abstract — Authors’ institutional publication record and abstractCited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.