NCT00380042: PROSPECT: implanted brain stimulation for depression

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Terminated

Study: PROSPECT, Northstar Neuroscience's investigation of implanted prefrontal cortical stimulation for treatment-resistant depression. 1 2

Design and measurements: This phase I feasibility protocol proposed an implanted stimulation system with a sham comparison. The record lists 12 anticipated participants. Unlike noninvasive repetitive transcranial magnetic stimulation, this approach involves surgically implanted equipment and therefore a materially different intervention and risk profile. 1 2

What is established: The historical record is terminated, with a December 2009 update. No verified response rate, remission rate, or adverse-event estimate was established from the inspected sources. The status does not by itself reveal why the study ended, and the proposed biological rationale should not be rewritten as demonstrated antidepressant benefit. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00380042. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00380042. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.