NCT00371085: COPE video education for heart-failure self-care

COPE tested a video-based self-care education program in heart failure. The randomized study enrolled 539 participants at 22 Canadian and US centers. The intervention combined a video, booklet, and follow-up newsletters; controls received the booklet. 1 2

At six months, the primary outcome—cardiovascular hospitalization or an emergency-department visit—occurred in 57 intervention participants, 21%, versus 61 controls, 23%; P=.66. Thus, the trial did not demonstrate a reduction in its primary outcome. Deaths were fewer in the intervention group: 18, 7%, versus 33, 12%; P=.03. 2

The mortality finding is important but should be interpreted separately from the negative primary endpoint rather than used to declare the whole intervention definitively effective. The study concerns a specific education package, not every form of heart-failure outreach or telemonitoring. 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00371085. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00371085. Original study registration: sponsor, design, population, endpoints and dated history.

2. Original full-text COPE randomized trial: Tsuyuki et al., 2019 — Original full-text COPE randomized trial: Tsuyuki et al., 2019Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.