NCT00359866: Helical radiation after cervical-cancer surgery

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Completed

Study: Pelvic intensity-modulated radiation delivered by helical tomotherapy after hysterectomy for cervical cancer with high-risk pathological features, at Washington University. 1 2

Design and measurements: This phase I study records 28 actual participants. The protocol used 50.4 Gy in 1.8-Gy fractions, approximately six weeks of radiation, with additional treatment such as chemotherapy or brachytherapy determined clinically. Its principal question was whether the technique could feasibly deliver the intended target coverage; toxicity and subsequent disease outcomes were also followed. 1 2

What is established: The record is completed, with a June 2016 update. No numerical toxicity, local-control, or survival result was verified. The protocol explicitly emphasizes feasibility rather than establishing comparative effectiveness, so it cannot support a claim of improved cure rates. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00359866. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00359866. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.