NCT00256074: Enteral feeds in critically ill ventilated patients

NCT00256074 compared enteral feeding formulations in critically ill, mechanically ventilated patients. Melbourne Health’s protocol randomized participants to a high-fat, lower-carbohydrate formula or a standard formulation. 1 2

The main physiological question was whether changing the fuel mixture reduced carbon-dioxide production and respiratory quotient, measured by indirect calorimetry during the early feeding period. Ventilator duration, length of stay, and mortality were additional outcomes. The inspected registry reproduction lists 30 participants and a terminated status, with an April 2017 update; an independently checked outcome-analysis denominator was not available. 1 2

Reducing carbon-dioxide production was the hypothesis, not a verified finding. No comparative ventilation, survival, or nutritional-safety results were established in the inspected material, and termination alone does not establish why the study stopped. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00256074. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00256074. Original study registration: sponsor, design, population, endpoints and dated history.

2. Inspected reproduction of the sponsor-submitted protocol. Readable registry-data reproduction, not an independent efficacy study — Inspected reproduction of the sponsor-submitted protocol. Readable registry-data reproduction, not an independent efficacy study.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.