NCT00161551: MODEST: pacing strategies for sick-sinus syndrome

Medicine Signal Editorial Desk
Updated 2026-10-10

Registry status when checked 2026-10-10Unknown

MODEST investigated pacing strategies for sick-sinus syndrome without high-degree atrioventricular block. The Medtronic/Vitatron study compared atrial pacing with dual-chamber approaches intended to minimize unnecessary ventricular pacing. 1 2

The prospective randomized multicenter record lists 402 anticipated participants, not a verified final sample. Atrial fibrillation and heart-failure outcomes were central clinical questions. Its status is unknown in a record last updated in 2011; old site-level recruitment labels are not evidence that enrollment remains open. 1 2

No verified event rates or comparative outcome estimates were recovered. The physiological rationale for avoiding unnecessary ventricular pacing should not be substituted for this trial’s results, and the appropriate mode for an individual patient depends on their conduction disease and device assessment. 1 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00161551. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00161551. Original study registration: sponsor, design, population, endpoints and dated history.

2. ICH GCP — ICH GCP — readable reproduction of the sponsor-submitted ClinicalTrials.gov record. Supports the registration details quoted here; not an independent clinical-results publication.Cited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.