NCT00120081: Na-ASP-2 hookworm vaccine: first human safety study

This was the first-in-human Na-ASP-2 hookworm-vaccine study in adults without previous hookworm infection. The randomized, double-blind, placebo-controlled trial enrolled 36 healthy adults. Three dose cohorts each contained nine vaccine recipients and three saline recipients; injections were scheduled on days 0, 56, and 112. 1 2 3

The original report found antibody responses after vaccination and no serious adverse events in this study. Injection-site reactions were generally mild or moderate, and delayed local reactions were reported. These are safety and immunogenicity findings, not proof that the vaccine prevented hookworm infection or disease. 2

Population matters: results in previously unexposed adults must not be merged with a different trial in previously infected participants. A vaccine's ability to generate antibodies and its suitability for an exposed population are distinct questions. 2

Sources

1. ClinicalTrials.gov — ClinicalTrials.gov — NCT00120081. Original study registration: sponsor, design, population, endpoints and dated history.Original study registration · Original record checked against the registry API. Checked 2026-10-10. Registration and current registry fields do not by themselves establish efficacy. Historical details in the article retain their stated date. Supplied note: ClinicalTrials.gov — NCT00120081. Original study registration: sponsor, design, population, endpoints and dated history.

2. PubMed — Bethony et al., original randomized trial, Vaccine 2008Research publication · Publication abstract read via Europe PMC; identifier and title cross-checked. Checked 2026-10-10. Full paper was not independently re-read for this update; abstract details should not be extended beyond what it reports.

3. Author-institution publication record — Author-institution publication recordCited supporting source · Link and description preserved from supplied research. Checked in supplied research dated 2026-10-10. Source description comes from supplied research; underlying page was not independently re-read for this update.